Laura M. Sack, PhD, FACMG

Publications

• Sack LM, Mertens L, Murphy E, Hutchinson L, Giersch ABS, Mason-Suares H. Leveraging Unique Chromosomal Microarray Probes to Accurately Detect Copy Number at the Highly Homologous 15q15.3 Deafness-Infertility Syndrome Locus. Clin Chem. 2023 Jun 1;69(6):583-594.

• Brandt T, Sack LM, Arjona D, Tan D, Mei H, Cui H, Gao H, Bean LJH, Ankala A, Del Gaudio D, Knight Johnson A, Vincent LM, Reavey C, Lai A, Richard G, Meck JM. Adapting ACMG/AMP sequence variant classification guidelines for single-gene copy number variants. Genet Med. 2020 Feb;22(2):336-344.

• Zirin J, Ni X, Sack LM, Yang-Zhou D, Bulyk M, Elledge SJ, Perrimon N. Interspecies analysis of MYC target genes identifies Aminoacyl tRNA synthetases as conserved mediators of growth and survival in MYC-overexpressing cells. Proc Natl Acad Sci. 2019 Jul 16;116(29):14614-14619.

• Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ. Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Cell. 2018 Apr 5;173(2):499-514.

• Sack LM, Davoli T, Xu Q, Li M, Elledge SJ. Sources of Error in Mammalian Genetic Screens. G3 (Bethesda). 2016 Sep 8;6(9):2781-90.

• Wang Y, Xu Q, Sack LM, Kang C, Elledge SJ. A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. Genes Dev. 2016 Feb 1;30(3):293-306.

• Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3781-6.

• Olive AJ, Haff MG, Emanuele MJ, Sack LM, Barker JR, Elledge SJ, Starnbach MN. Chlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth. Cell Host Microbe. 2014 Jan 15;15(1):113-24.

• Davoli T*, Xu AW*, Mengwasser KE+, Sack LM+, Yoon JC, Park PJ, Elledge SJ. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell. 2013 Nov 7;155(4):948-62.

  *Authors contributed equally to this work
  + Authors contributed equally to this work

• Hoe HS*, Magill LA*, Guenette S, Fu Z, Vicini S, Rebeck GW. FE65 interaction with the ApoE receptor ApoEr2. J Biol Chem. 2006 Aug 25;281(34):24521-30.

  *Authors contributed equally to this work